Article
Monocyte-derived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profile.
Liver international : official journal of the International Association for the Study of the Liver - 1 Sept 2007
Gelderblom Huub C, Nijhuis Laurens E J, de Jong Esther C, te Velde Anje A, Pajkrt Dasja, Reesink Henk W, Beld Marcel G H M, van Deventer Sander J H, Jansen Peter L M
Abstract excerpt
BACKGROUND: Chronic hepatitis C virus (HCV) infection is characterized by an insufficient immune response, possibly owing to impaired function of antigen-presenting cells such as myeloid dendritic cells (DCs). Therapeutic vaccination with in vitro generated DCs may enhance the immune response. Subsets of DCs can originate from monocytes, but the presence of HCV in monocytes that develop into DCs in vitro may...
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