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Article

Lymphocyte signaling: beyond knockouts.

Nature immunology - 1 Apr 2009

Saveliev Alexander, Tybulewicz Victor L J

Abstract excerpt

The analysis of lymphocyte signaling was greatly enhanced by the advent of gene targeting, which allows the selective inactivation of a single gene. Although this gene 'knockout' approach is often informative, in many cases, the phenotype resulting from gene ablation might not provide a complete picture of the function of the corresponding protein. If a protein has multiple functions within a single or several...

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Identifiers

PMID: 19295633
DOI: 10.1038/ni.1709
PMCID: PMC4898592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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