Article
Molecular characterisation of camptothecin-induced mutations at the hprt locus in Chinese hamster cells.
Mutation research - 9 May 2001
Balestrieri E, Zanier R, Degrassi F
Abstract excerpt
The capacity of the topoisomerase I inhibitor camptothecin (CPT) to induce single locus mutations at the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene and the DNA changes underlying induced mutations were analysed in Chinese hamster ovary cells. Camptothecin treatments increased hprt mutations up to 50-fold over the spontaneous levels at highly cytotoxic doses. Genomic DNA was isolated from...
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