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Article

Mechanisms of Cellular Resistance to Camptothecins

30 Oct 2006

Abstract excerpt

The camptothecins are among the most promising antitumor agents endowed with a unique mechanism of action, because they act through inhibition of DNA topoisomerase I, an enzyme involved in regulating critical cellular functions including DNA replication, transcription and recombination. On the basis of the pharmacological interest of camptothecins in cancer chemotherapy, medicinal chemistry has played a crucial...

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PMID: 17168852
DOI: 10.2174/092986706778773121

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Source receipt: pubmed, retrieved 7 Sept 2026.

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