Article
Effect of chemotherapy on the mutation frequency of ovarian cancer cells at the HPRT locus.
Anticancer research - 1 Jan 2000
Gercel-Taylor Cicek, Scobee Jeremy J, Taylor Douglas D
Abstract excerpt
OBJECTIVE: Resistance to chemotherapy in ovarian cancers is a difficult problem. Our objective was to demonstrate the effect of chemotherapeutic agents, used in the treatment of ovarian cancer, on the mutation frequency of ovarian cancer cells at the HPRT locus. MATERIALS AND METHODS: Single cell clones were isolated from a recently established ovarian cancer cell line. The cells were then exposed to sublethal...
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