Immunoglobulin VH gene expression in human aging.

doi:10.1006/clim.1999.4781

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Article

Immunoglobulin VH gene expression in human aging.

Clinical immunology (Orlando, Fla.) - 1 Nov 1999

Wang X, Stollar B D

Abstract excerpt

Immune responses change in aging humans, but it is not known whether there is an age-associated change in the expressed B cell repertoire. We compared Ig VH cDNA libraries from circulating B cells of five elderly and three young human adults. As in young persons, nearly two-thirds of the cDNA clones from older subjects had zero to three V(H) mutations, although there was more individual variation among the...

Topics

Adult
Aged
Aging
DNA, Complementary
Gene Expression Regulation
Gene Frequency
Gene Library
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genes, Immunoglobulin
Humans
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin J-Chains

Immunoglobulin Variable Region

Molecular Sequence Data

Mutation

Protein Structure, Tertiary

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 10527689
DOI: 10.1006/clim.1999.4781

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