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Article

Sex-Biased Aging Effects on Ig Somatic Hypermutation Targeting.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2021

Cui Ang, Chawla Daniel G, Kleinstein Steven H

Abstract excerpt

Aged individuals, particularly males, display an impaired level of Ab response compared with their younger counterparts, yet the molecular mechanisms responsible for the discrepancy are not well understood. We hypothesize that some of this difference may be linked to B cell somatic hypermutation (SHM) targeting, including error-prone DNA repair activities that are crucial to Ab diversification. To examine the...

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Identifiers

PMID: 33288546
DOI: 10.4049/jimmunol.2000576
PMCID: PMC8582005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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