Article

Multi-stage models for the failure of complex systems, cascading disasters, and the onset of disease

2018-11-27

Abstract excerpt

Complex systems can fail through different routes, often progressing through a series of (rate-limiting) steps and modified by environmental exposures. The onset of disease, cancer in particular, is no different. Multi-stage models provide a simple but very general mathematical framework for studying the failure of complex systems, or equivalently, the onset of disease. They include the Armitage-Doll multi-stage c...

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Literature Corpus work: d64917e2-8247-5221-ba8e-93ac5f714523
DOI: 10.1101/476242

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