Identifying dose dependences of the two-stage clonal expansion model with simulated cohorts.

doi:10.1088/0952-4746/22/3a/310

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Article

Identifying dose dependences of the two-stage clonal expansion model with simulated cohorts.

Journal of radiological protection : official journal of the Society for Radiological Protection - 1 Sept 2002

Kaiser J C, Heidenreich W F

Abstract excerpt

The two-stage clonal expansion model of cancer induction is tested on recorded and simulated cohort data of radon-exposed rats. Unfortunately, different versions of the model, for which radiation acts on different biological processes, can provide a good description of the data. This is the case for an initiation-transformation and an initiation-promotion model when they are applied to lung tumour data of...

Topics

Animals
Cell Transformation, Neoplastic
Dose-Response Relationship, Radiation
Lung Neoplasms
Models, Biological
Mutation
Neoplasms, Radiation-Induced
Radiation Dosage
Radon
Rats

Source

Open in PubMed

Identifiers

PMID: 12400948
DOI: 10.1088/0952-4746/22/3a/310

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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