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Article

Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase.

Genes & development - 1 May 2001

Chi Y, Huddleston M J, Zhang X, Young R A, Annan R S, Carr S A, Deshaies R J

Abstract excerpt

The budding yeast transcriptional activator Gcn4 is rapidly degraded in an SCF(Cdc4)-dependent manner in vivo. Upon fractionation of yeast extracts to identify factors that mediate Gcn4 ubiquitination, we found that Srb10 phosphorylates Gcn4 and thereby marks it for recognition by SCF(Cdc4) ubiquitin ligase. Srb10 is a physiological regulator of Gcn4 stability because both phosphorylation and turnover of Gcn4 are...

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PMID: 11331604
DOI: 10.1101/gad.867501
PMCID: PMC312682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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