Article
Nucleocytoplasmic trafficking of G2/M regulators in yeast.
Molecular biology of the cell - 1 Sept 2008
Keaton Mignon A, Szkotnicki Lee, Marquitz Aron R, Harrison Jake, Zyla Trevin R, Lew Daniel J
Abstract excerpt
Nucleocytoplasmic shuttling is prevalent among many cell cycle regulators controlling the G2/M transition. Shuttling of cyclin/cyclin-dependent kinase (CDK) complexes is thought to provide access to substrates stably located in either compartment. Because cyclin/CDK shuttles between cellular compartments, an upstream regulator that is fixed in one compartment could in principle affect the entire cyclin/CDK pool....
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