Article
Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback.
Molecular cell - 1 Aug 2006
de Bruin Robertus A M, Kalashnikova Tatyana I, Chahwan Charly, McDonald W Hayes, Wohlschlegel James, Yates John, Russell Paul, Wittenberg Curt
Abstract excerpt
G1-specific transcription in yeast depends upon SBF and MBF. We have identified Nrm1 (negative regulator of MBF targets 1), as a stable component of MBF. NRM1 (YNR009w), an MBF-regulated gene expressed during late G1 phase, associates with G1-specific promoters via MBF. Transcriptional repression upon exit from G1 phase requires both Nrm1 and MBF. Inactivation of Nrm1 results in prolonged expression of...
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