Article
Nuclear localization destabilizes the stress-regulated transcription factor Msn2.
The Journal of biological chemistry - 31 Dec 2004
Durchschlag Erich, Reiter Wolfgang, Ammerer Gustav, Schüller Christoph
Abstract excerpt
The transcriptional program of yeast cells undergoes dramatic changes during the shift from fermentative growth to respiratory growth. A large part of this response is mediated by the stress responsive transcription factor Msn2. During glucose exhaustion, Msn2 is activated and concentrated in the nucleus. Simultaneously, Msn2 protein levels also drop significantly under this condition. Here we show that the...
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