Article
Genetic factors that regulate the attenuation of the general stress response of yeast.
Genetics - 1 Mar 2005
Bose Sohini, Dutko James A, Zitomer Richard S
Abstract excerpt
The general stress response of yeast involves the induction of approximately 200 genes in response to any one of several stresses. These genes are activated by Msn2 and repressed by the Srb10 kinase, a member of the mediator complex. Normally, Msn2 is exported from the nucleus, and Srb10 represses STRE gene expression. Under stress, Msn2 relocalizes to the nucleus and, with the relief of Srb10 repression,...
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