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Article

Surprising complexity of the Asf1 histone chaperone-Rad53 kinase interaction.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2012

Jiao Yue, Seeger Karsten, Lautrette Aurelie, Gaubert Albane, Mousson Florence, Guerois Raphael, Mann Carl, Ochsenbein Françoise

Abstract excerpt

The histone chaperone Asf1 and the checkpoint kinase Rad53 are found in a complex in budding yeast cells in the absence of genotoxic stress. Our data suggest that this complex involves at least three interaction sites. One site involves the H3-binding surface of Asf11 with an as yet undefined surface of Rad53. A second site is formed by the Rad53-FHA1 domain binding to Asf1-T(270) phosphorylated by casein kinase...

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PMID: 22323608
DOI: 10.1073/pnas.1106023109
PMCID: PMC3286907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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