Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclin-dependent kinase-mediated phosphorylation plays a critical role in the oncogenic functions of PELP1.

Cancer research - 15 Sept 2010

Nair Binoj C, Nair Sujit S, Chakravarty Dimple, Challa Rambabu, Manavathi Bramanandam, Yew P Renee, Kumar Rakesh, Tekmal Rajeshwar Rao, Vadlamudi Ratna K

Abstract excerpt

Estrogen receptor (ER) signaling plays an important role in breast cancer progression, and ER functions are influenced by coregulatory proteins. PELP1 (proline-, glutamic acid-, and leucine-rich protein 1) is a nuclear receptor coregulator that plays an important role in ER signaling. Its expression is deregulated in hormonal cancers. We identified PELP1 as a novel cyclin-dependent kinase (CDK) substrate. Using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Co-Repressor Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase 2

Share to Cyclin-Dependent Kinases

Share to E2F Transcription Factors

Share to Mice, Nude

Share to NIH 3T3 Cells

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 20807815
DOI: 10.1158/0008-5472.CAN-10-0628
PMCID: PMC3058498

Genes

PELP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclin-dependent kinase-mediated phosphorylation plays a critical role in the oncogenic functions of PELP1.PMID 20807815Read ↗

PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.Semantic proximity Read ↗

Role of PELP1/MNAR Signaling in Ovarian TumorigenesisSemantic proximity Read ↗

Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling.Semantic proximity Read ↗

Prevalent overexpression of prolyl isomerase Pin1 in human cancers.Semantic proximity Read ↗

Molecular Cloning and Characterization of PELP1, a Novel Human Coregulator of Estrogen Receptor αSemantic proximity Read ↗

Novel role of PELP1 in regulating chemotherapy response in mutant p53-expressing triple negative breast cancer cells.Semantic proximity Read ↗

Estrogen regulates PDPK1 to promote cell proliferation in epithelial ovarian cancerSemantic proximity Read ↗

Kinome-wide Functional Screen Identifies Role of PLK1 in Hormone-Independent, ER-Positive Breast CancerSemantic proximity Read ↗

Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosisSemantic proximity Read ↗

Cracking the estrogen receptor's posttranslational code in breast tumors.Semantic proximity Read ↗

Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells.Semantic proximity Read ↗

Stabilization of GTSE1 by cyclin D1-CDK4/6-mediated phosphorylation promotes cell proliferation: relevance in cancer prognosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.