The estrogen receptor variant lacking exon 5 has dominant negative activity in the human breast epithelial cell line HMT-3522S1.

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Article

The estrogen receptor variant lacking exon 5 has dominant negative activity in the human breast epithelial cell line HMT-3522S1.

Cancer research - 1 Oct 1998

Ohlsson H, Lykkesfeldt A E, Madsen M W, Briand P

Abstract excerpt

The estrogen receptor variant lacking exon 5 (ERdeltaE5) encodes a truncated protein that lacks the hormone-binding domain and has been suggested to be responsible for the estrogen-independent growth of human breast tumors and resistance to antiestrogen therapy. The biological function of the ERd...

Topics

Breast
Cell Line
Chloramphenicol O-Acetyltransferase
Epithelial Cells
Exons
Female
Genetic Variation
Humans
RNA, Messenger
Receptors, Estrogen
Recombinant Fusion Proteins
Sequence Deletion
Transcription, Genetic
Transfection
beta-Galactosidase

Source

Open in PubMed

Identifiers

PMID: 9766649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9766649-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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