Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The estrogen receptor variant lacking exon 5 has dominant negative activity in the human breast epithelial cell line HMT-3522S1.

Cancer research - 1 Oct 1998

Ohlsson H, Lykkesfeldt A E, Madsen M W, Briand P

Abstract excerpt

The estrogen receptor variant lacking exon 5 (ERdeltaE5) encodes a truncated protein that lacks the hormone-binding domain and has been suggested to be responsible for the estrogen-independent growth of human breast tumors and resistance to antiestrogen therapy. The biological function of the ERdeltaE5 in human breast epithelial cells has been studied by transient transfection of HMT-3522S1 cells with wild-type...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Exons
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Recombinant Fusion Proteins

Share to RNA, Messenger

Share to Sequence Deletion

Share to Transcription, Genetic

Share to Transfection

Source

Identifiers

PMID: 9766649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The estrogen receptor variant lacking exon 5 has dominant negative activity in the human breast epithelial cell line HMT-3522S1.PMID 9766649Read ↗

An exon 5 deletion variant of the estrogen receptor frequently coexpressed with wild-type estrogen receptor in human breast cancer.Semantic proximity Read ↗

Estrogen receptor variants ERdelta5 and ERdelta7 down-regulate wild-type estrogen receptor activity.Semantic proximity Read ↗

Expression of estrogen receptor variants.Semantic proximity Read ↗

Mutations in the estrogen receptor gene.Semantic proximity Read ↗

The pathophysiological role of estrogen receptor variants in human breast cancer.Semantic proximity Read ↗

A novel estrogen receptor variant mRNA lacking exons 4 to 6 in breast carcinoma.Semantic proximity Read ↗

The regulation of estrogen receptor expression and function in human breast cancer.Semantic proximity Read ↗

Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors.Semantic proximity Read ↗

Role of estrogen receptor variants in the development of hormone resistance in breast cancer.Semantic proximity Read ↗

A transcriptionally active estrogen receptor mutant is a novel type of dominant negative inhibitor of estrogen action.Semantic proximity Read ↗

Estrogen receptor variants and mutations.Semantic proximity Read ↗

Effects of exon-deleted estrogen receptor β transcript variants on growth, apoptosis and gene expression of human breast cancer cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.