An exon 5 deletion variant of the estrogen receptor frequently coexpressed with wild-type estrogen receptor in human breast cancer.

Article

An exon 5 deletion variant of the estrogen receptor frequently coexpressed with wild-type estrogen receptor in human breast cancer.

Cancer research - 15 Dec 1993

Zhang Q X, Borg A, Fuqua S A

Abstract excerpt

Recent evidence suggests that the expression of estrogen receptor (ER) variants in breast cancer may interfere with wild-type (wt) ER function and be related to tumor progression and resistance to hormone treatment. One of these variants, ER delta E5, lacking that part of the hormone-binding doma...

Topics

Breast Neoplasms
Exons
Female
Gene Deletion
Humans
Phenotype
Receptors, Estrogen
Receptors, Progesterone
Tumor Cells, Cultured

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