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Article

An exon 5 deletion variant of the estrogen receptor frequently coexpressed with wild-type estrogen receptor in human breast cancer.

Cancer research - 15 Dec 1993

Zhang Q X, Borg A, Fuqua S A

Abstract excerpt

Recent evidence suggests that the expression of estrogen receptor (ER) variants in breast cancer may interfere with wild-type (wt) ER function and be related to tumor progression and resistance to hormone treatment. One of these variants, ER delta E5, lacking that part of the hormone-binding domain encoded by exon 5, has previously been identified in breast tumors with the unusual estrogen receptor negative (ER-)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8261397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An exon 5 deletion variant of the estrogen receptor frequently coexpressed with wild-type estrogen receptor in human breast cancer.PMID 8261397Read ↗

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Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors.Semantic proximity Read ↗

Estrogen receptor variants ERdelta5 and ERdelta7 down-regulate wild-type estrogen receptor activity.Semantic proximity Read ↗

Identification of wild-type and exon 5 deletion variants of estrogen receptor beta in normal human mammary gland.Semantic proximity Read ↗

Estrogen receptor alpha mRNA variant lacking exon 5 is co-expressed with the wild-type in endometrial adenocarcinoma.Semantic proximity Read ↗

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Estrogen receptor variants are present in many normal human tissues.Semantic proximity Read ↗

Estrogen receptors: new perspectives in breast cancer management.Semantic proximity Read ↗

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