TKO'ed: lox, stock and barrel.

Abstract excerpt

The generation of panels of mutant mice by homologous recombination has greatly increased the ability to assess the function of particular gene products in vivo. The ability to control the developmental stage, the tissue and the nature of the mutation would be an important innovation. A recent report demonstrates that the conservative site-specific recombination of bacteriophage P1, namely Cre-lox, can be used...

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