Mechanism underlying slow kinetics of the OFF gating current in Shaker potassium channel.

doi:10.1016/S0006-3495(01)76189-9

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Article

Mechanism underlying slow kinetics of the OFF gating current in Shaker potassium channel.

Biophysical journal - 1 May 2001

Melishchuk A, Armstrong C M

Abstract excerpt

Based on the structure of the KcsA potassium channel, the Shaker K+ channel is thought to have, near the middle of the membrane, a cavity that can be occupied by a permeant or a blocking cation. We have studied the interaction between cations in the cavity and the activation gate of the channel, using a set of monovalent cations together with Shaker mutants that modify the structure of the cavity. Our results...

Topics

Alanine
Cations
Cell Line
Cysteine
Humans
Ions
Kinetics
Leucine
Meglumine
Models, Biological
Mutation
Potassium Channels
Shaker Superfamily of Potassium Channels
Tetraethylammonium
Transfection

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Identifiers

PMID: 11325719
DOI: 10.1016/S0006-3495(01)76189-9
PMCID: PMC1301408

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