Article
Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels.
Neuron - 1 Aug 1993
Perozo E, MacKinnon R, Bezanilla F, Stefani E
Abstract excerpt
In voltage-dependent ion channels, a voltage sensor region is responsible for channel activation and an aqueous pore is responsible for ion conduction. These two processes have been traditionally considered to be independent. We describe here a mutation in the putative pore region (W434F) that completely abolishes ion conduction without affecting the gating charge of the channel. Gating currents in the...
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