Host modifier genes affect mouse autoimmunity induced by the lpr gene.

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Article

Host modifier genes affect mouse autoimmunity induced by the lpr gene.

The American journal of pathology - 1 Dec 1997

Wang Y, Nose M, Kamoto T, Nishimura M, Hiai H

Abstract excerpt

A defect in apoptotic signal transmission through CD95 is an essential genetic mechanism for lymphoproliferation and autoimmunities in lpr or gld mice. However, disease manifestations are largely affected by the host genetic background. To identify and map such host genes modifying lpr gene effec...

Topics

Animals
Antibodies, Antinuclear
Autoimmunity
Chromosome Aberrations
Chromosome Disorders
Chromosome Mapping
Chromosomes
DNA
Female
Genotype
Glomerulonephritis
Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoid Tissue

Male

Mice

Mice, Inbred C3H

Mice, Inbred MRL lpr

Microsatellite Repeats

Source

Open in PubMed Open full text

Identifiers

PMID: 9403730
PMCID: PMC1858355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9403730-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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