Article
Host modifier genes affect mouse autoimmunity induced by the lpr gene.
The American journal of pathology - 1 Dec 1997
Wang Y, Nose M, Kamoto T, Nishimura M, Hiai H
Abstract excerpt
A defect in apoptotic signal transmission through CD95 is an essential genetic mechanism for lymphoproliferation and autoimmunities in lpr or gld mice. However, disease manifestations are largely affected by the host genetic background. To identify and map such host genes modifying lpr gene effect, ie, the lpr modifier (Lprm) genes, 82 MRL/lpr x (MRL/lpr x C3H/lpr) F1 mice were subjected to immunopathological and...
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