Article
Genetic basis of tissue specificity of vasculitis in MRL/lpr mice.
Arthritis and rheumatism - 1 May 2003
Yamada Akihiro, Miyazaki Tatsuhiko, Lu Ling-Min, Ono Masao, Ito Mitsuko R, Terada Miho, Mori Shiro, Hata Kazuya, Nozaki Yoshimi, Nakatsuru Shuichi, Nakamura Yusuke, Onji Morikazu, Nose Masato
Abstract excerpt
OBJECTIVE: To clarify the mode of inheritance of the tissue distribution of vasculitis in MRL/Mp-lpr/lpr (MRL/lpr) lupus-prone mice and to identify the susceptibility loci. METHODS: Vasculitis in individual MRL/lpr, C3H/HeJ-lpr/lpr (C3H/lpr), (MRL/lpr x C3H/lpr)F(1), and (MRL/lpr x C3H/lpr)F(2) intercross mice was analyzed by histopathologic grading of main branches of the aorta and of medium-sized arteries in...
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