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Article

Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains.

Arthritis and rheumatism - 1 Apr 2002

Kamogawa Junji, Terada Miho, Mizuki Shinichi, Nishihara Miyuki, Yamamoto Haruyasu, Mori Shiro, Abe Yoriko, Morimoto Koji, Nakatsuru Syuichi, Nakamura Yusuke, Nose Masato

Abstract excerpt

OBJECTIVE: To clarify the mode of inheritance and the genome origins of arthritis in a lupus-prone strain of mice, MRL/MpJ, bearing a Fas deletion mutant gene, lpr (MRL/lpr). METHODS: Using non-lupus-prone strains of mice, C3H/HeJ-lpr/lpr (C3H/lpr), (MRL/lpr x C3H/lpr)F(1) intercross and MRL/lpr x (MRL/lpr x C3H/lpr)F(1) backcross mice were prepared. Arthritis in individual mice was analyzed by histopathologic...

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PMID: 11953986
DOI: 10.1002/art.10193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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