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Article

p53 independent G1 arrest and apoptosis induced by adriamycin.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih - 1 Jun 1997

Shao Z, Jiang M, Yu L, Han Q, Shen Z

Abstract excerpt

The biological activity of adriamycin was investigated in human breast carcinoma (HBC) cells, Adriamycin inhibited the growth of a number of HBC cell lines and induced G1 arrest followed by apoptosis. In MCF-7 cells that harbor wild-type p53, adriamycin-induced G1 arrest and apoptosis was accompanied by p53-independent regulation of WAF1/CIP1 as well as bax mRNA levels. In MDA-MB-231 cells which possess a mutant...

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PMID: 11324502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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