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Article

11a-N-Tosyl-5-deoxi-pterocarpan, LQB-223, a novel compound with potent antineoplastic activity toward breast cancer cells with different phenotypes.

Journal of cancer research and clinical oncology - 1 Oct 2016

Lemos Lauana Greicy Tonon, Nestal de Moraes Gabriela, Delbue Deborah, Vasconcelos Flavia da Cunha, Bernardo Paula Sabbo, Lam Eric W-F, Buarque Camilla Djenne, Costa Paulo Ribeiro, Maia Raquel Ciuvalschi

Abstract excerpt

UNLABELLED: Multidrug resistance is the major obstacle for successful treatment of breast cancer, prompting the investigation of novel anticancer compounds. PURPOSE: In this study, we tested whether LQB-223, an 11a-N-Tosyl-5-deoxi-pterocarpan newly synthesized compound, could be effective toward breast cancer cells. METHODS: Human breast cell lines MCF-7, MDA-MB-231, HB4a and MCF-7 Dox(R) were used as models for...

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PMID: 27520309
DOI: 10.1007/s00432-016-2212-6

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