Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of p53 in G2/M cell cycle arrest and apoptosis in response to gamma-irradiation in ovarian carcinoma cell lines.

International journal of oncology - 1 Jan 2003

Concin Nicole, Stimpfl Margit, Zeillinger Christa, Wolff Uwe, Hefler Lukas, Sedlak Jan, Leodolter Sepp, Zeillinger Robert

Abstract excerpt

We investigated the cell cycle and apoptotic response to irradiation in 4 human ovarian carcinoma cell lines, i.e., PA-1, Caov-3, SK-OV-3, and ES-2. Cell lines were also analysed for their p53 and Bax expression to address the relationship with cell cycle and apoptotic response. Apoptosis was exa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-2-Associated X Protein
Share to G2 Phase
Share to Gamma Rays

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitosis

Share to Ovarian Neoplasms

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-bcl-2

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12469184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12469184-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of p53 in G2/M cell cycle arrest and apoptosis in response to gamma-irradiation in ovarian carcinoma cell lines.PMID 12469184Read ↗

Role of p53 mutations in the radiosensitivity status of tumor cells.Semantic proximity Read ↗

[Antioncogene p53 and apoptosis response: new hypotheses on the molecular bases of tumor resistance to radiotherapy].Semantic proximity Read ↗

Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cellsSemantic proximity Read ↗

BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: a mechanism of resistance to multiple anticancer agentsSemantic proximity Read ↗

Effects of p53 mutations on cellular sensitivity to ionizing radiation.Semantic proximity Read ↗

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.Semantic proximity Read ↗

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.Semantic proximity Read ↗

Expression of P53, P21/WAF/CIP, BCL-2, BAX, BCL-X, and BAK In Radiation-Induced Apoptosis in Testicular Germ Cell Tumor LinesSemantic proximity Read ↗

Expression of factors involved in regulation of DNA mismatch repair- and apoptosis pathways in ovarian cancer patientsSemantic proximity Read ↗

Role of Apoptosis in Low-Dose Hyper-radiosensitivitySemantic proximity Read ↗

Role of Three Cancer ≪Master Genes≫ P53, Bcl2 and C-Myc on the Apoptotic ProcessSemantic proximity Read ↗

Insights into apoptosis mechanisms induced by DNA-damaging agents in Burkitt's lymphoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.