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Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells.

Carcinogenesis - 1 Feb 2010

Lahiry Lakshmishri, Saha Baisakhi, Chakraborty Juni, Adhikary Arghya, Mohanty Suchismita, Hossain Dewan Md Sakib, Banerjee Shuvomoy, Das Kaushik, Sa Gaurisankar, Das Tanya

Abstract excerpt

The most common alterations found in breast cancer are inactivation or mutation of tumor suppressor gene p53. The present study revealed that theaflavins induced p53-mutated human breast cancer cell apoptosis. Pharmacological inhibition of caspase-8 or expression of dominant-negative (Dn)-caspase...

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Identifiers

PMID: 19969555
DOI: 10.1093/carcin/bgp240

Genes

FADD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19969555-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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