Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic mechanisms for variability in drug response and toxicity.

Journal of analytical toxicology - 1 Jan 2000

Linder M W, Valdes R

Abstract excerpt

It is now well established that many proteins involved in the metabolism or pharmacodynamic action of drugs and foreign compounds exhibit structural polymorphism and variation in their level of expression. This variation leads to dramatic phenotypic differences in response to medicines or susceptibility to carcinogenesis. Some of the changes in the phenotypic expression of proteins are secondary to variation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dose-Response Relationship, Drug
Share to Drug-Related Side Effects and Adverse Reactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genetic Variation

Share to Multigene Family

Share to Polymorphism, Genetic

Share to Xenobiotics

Source

Identifiers

PMID: 11499898
DOI: 10.1093/jat/25.5.405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic mechanisms for variability in drug response and toxicity.PMID 11499898Read ↗

Pharmacogenomics: the influence of genomic variation on drug response.Semantic proximity Read ↗

Advances in pharmacogenetics and pharmacogenomics.Semantic proximity Read ↗

[Cancer pharmacogenetics: study of genetically determined variations on cancer susceptibility due to xenobiotic exposure].Semantic proximity Read ↗

Pharmacogenomics: the genetics of variable drug responses.Semantic proximity Read ↗

Pharmacogenomics: marshalling the human genome to individualise drug therapySemantic proximity Read ↗

Genetic variability in susceptibility and response to toxicants.Semantic proximity Read ↗

Regulatory polymorphisms and their contribution to interindividual differences in the expression of enzymes influencing drug and toxicant disposition.Semantic proximity Read ↗

Role of pharmacogenomics in the drug development.Semantic proximity Read ↗

Genetic factors in drug metabolism.Semantic proximity Read ↗

The legacy of pharmacogenetics and potential applications.Semantic proximity Read ↗

Relating human genetic variation to variation in drug responses.Semantic proximity Read ↗

Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.