Article
Different expression of P14ARF defines two groups of breast carcinomas in terms of TP73 expression and TP53 mutational status.
Genes, chromosomes & cancer - 1 Jun 2001
Domínguez G, Silva J, Silva J M, García J M, Larrondo F J, Vargas J, Sanfrutos L, Provencio M, España P, Bonilla F
Abstract excerpt
In 95 breast carcinomas, we investigated P14ARF and TP73 mRNA expression and their relationship to TP53 mutations, determined by an immunohistochemical method, studying several clinicopathologic features of the tumors. P14ARF and TP73 mRNA levels were determined by semiquantitative reverse transcription polymerase chain reaction (RT-PCR), using beta-actin as a control. P14ARF was overexpressed in 19% of the cases...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
