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Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1p

29 Jan 2001

Abstract excerpt

DNA polymerase zeta (Pol zeta) and Rev1p carry out translesion replication in budding yeast, Saccharomyces cerevisiae, and are jointly responsible for almost all base pair substitution and frameshift mutations induced by DNA damage in this organism. In addition, Pol zeta is responsible for the majority of spontaneous mutations in yeast and has been proposed as the enzyme responsible for somatic hypermutability....

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PMID: 11205328
DOI: 10.1098/rstb.2000.0001

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