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Article

Mutagenic effects of abasic and oxidized abasic lesions in Saccharomyces cerevisiae.

Nucleic acids research - 1 Jan 2005

Kow Yoke W, Bao Gaobin, Minesinger Brenda, Jinks-Robertson Sue, Siede Wolfram, Jiang Yu Lin, Greenberg Marc M

Abstract excerpt

2-deoxyribonolactone (L) and 2-deoxyribose (AP) are abasic sites that are produced by ionizing radiation, reactive oxygen species and a variety of DNA damaging agents. The biological processing of the AP site has been examined in the yeast Saccharomyces cerevisiae. However, nothing is known about how L is processed in this organism. We determined the bypass and mutagenic specificity of DNA containing an abasic...

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Identifiers

PMID: 16257982
DOI: 10.1093/nar/gki926
PMCID: PMC1275587

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