Article
A study of interleukin-1 cluster genes in susceptibility to and severity of multiple sclerosis.
Journal of the neurological sciences - 1 Apr 2001
Luomala M, Lehtimäki T, Elovaara I, Wang X, Ukkonen M, Mattila K, Laippala P, Koivula T, Hurme M
Abstract excerpt
In this explorative study, interleukin-1 (IL-1) receptor antagonist (IL-1RA; polymorphism of variable number of tandem repeats: VNTR), IL-1alpha (-889), IL-1beta (-511) and IL-1beta (+3953) polymorphisms were studied in relation to susceptibility to and severity of multiple sclerosis (MS), in 93 MS patients and 400 normal controls. No associations were found for any polymorphisms, alone or in combination....
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