Article
Association of two variants in IL-1beta and IL-1 receptor antagonist genes with multiple sclerosis.
Journal of neuroimmunology - 1 Jul 2000
Kantarci O H, Atkinson E J, Hebrink D D, McMurray C T, Weinshenker B G
Abstract excerpt
We studied the putative association of a C-->T polymorphism in exon-5 of IL-1beta and an 85 bp tandem repeat in intron-4 of IL-1 receptor antagonist (IL-1ra) genes with susceptibility to or outcome of MS. DNA from 122 cases from a population-based cohort in Olmsted County, MN who were previously categorized for disease severity and temporal course and 244 ethnically-matched controls were analyzed. There was no...
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