Article
The interleukin-1 gene family in multiple sclerosis susceptibility and disease course.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Dec 2003
Hooper-van Veen Tineke, Schrijver Hans M, Zwiers Antoon, Crusius J Bart A, Knol Dirk L, Kalkers Nynke F, Laine Marja L, Barkhof Frederik, Peña A Salvador, Polman Chris H, Uitdehaag Bernard M J
Abstract excerpt
Multiple sclerosis (MS) is a chronic disease of presumed autoimmune origin with a considerable polygenic influence. We have previously observed that a specific allele combination in genes of the interleukin-1 (IL-1) family influenced the progression rate in MS. We have considerably expanded our p...
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