Article
The interleukin-1 gene family in multiple sclerosis susceptibility and disease course.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Dec 2003
Hooper-van Veen Tineke, Schrijver Hans M, Zwiers Antoon, Crusius J Bart A, Knol Dirk L, Kalkers Nynke F, Laine Marja L, Barkhof Frederik, Peña A Salvador, Polman Chris H, Uitdehaag Bernard M J
Abstract excerpt
Multiple sclerosis (MS) is a chronic disease of presumed autoimmune origin with a considerable polygenic influence. We have previously observed that a specific allele combination in genes of the interleukin-1 (IL-1) family influenced the progression rate in MS. We have considerably expanded our patient population (492 MS patients and 228 controls). In the present study, we investigated the role of the IL-IA--889,...
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