Article
Model-free linkage analysis with covariates confirms linkage of prostate cancer to chromosomes 1 and 4.
American journal of human genetics - 1 May 2001
Goddard K A, Witte J S, Suarez B K, Catalona W J, Olson J M
Abstract excerpt
As with many complex genetic diseases, genome scans for prostate cancer have given conflicting results, often failing to provide replication of previous findings. One factor contributing to the lack of consistency across studies is locus heterogeneity, which can weaken or even eliminate evidence for linkage that is present only in a subset of families. Currently, most analyses either fail to account for locus...
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