Article
Prostate cancer segregation analyses using 4390 families from UK and Australian population-based studies.
Genetic epidemiology - 1 Jan 2010
MacInnis Robert J, Antoniou Antonis C, Eeles Rosalind A, Severi Gianluca, Guy Michelle, McGuffog Lesley, Hall Amanda L, O'Brien Lynne T, Wilkinson Rosemary A, Dearnaley David P, Ardern-Jones Audrey T, Horwich Alan, Khoo Vincent S, Parker Christopher C, Huddart Robert A, McCredie Margaret R, Smith Charmaine, Southey Melissa C, Staples Margaret P, English Dallas R, Hopper John L, Giles Graham G, Easton Douglas F
Abstract excerpt
Familial aggregation of prostate cancer is likely to be due to multiple susceptibility loci, perhaps acting in conjunction with shared lifestyle risk factors. Models that assume a single mode of inheritance may be unrealistic. We analyzed genetic models of susceptibility to prostate cancer using segregation analysis of occurrence in families ascertained through population-based series totaling 4390 incident...
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