Article
Clinical characteristics of prostate cancer in an analysis of linkage to four putative susceptibility loci.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2001
Goode E L, Stanford J L, Peters M A, Janer M, Gibbs M, Kolb S, Badzioch M D, Hood L, Ostrander E A, Jarvik G P
Abstract excerpt
PURPOSE: Hereditary prostate cancer is an etiologically heterogeneous disease with six susceptibility loci mapped to date. We aimed to describe a collection of high-risk prostate cancer families and assess linkage to multiple markers at four loci: HPC1 (1q24-25), PCaP (1q42.2-43), HPCX (Xq27-28), and CAPB (1p36). EXPERIMENTAL DESIGN: Medical record data on 505 affected men in 149 multiply-affected prostate cancer...
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