Article
Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers.
Cancer research - 1 Apr 2001
Kim H L, Vander Griend D J, Yang X, Benson D A, Dubauskas Z, Yoshida B A, Chekmareva M A, Ichikawa Y, Sokoloff M H, Zhan P, Karrison T, Lin A, Stadler W M, Ichikawa T, Rubin M A, Rinker-Schaeffer C W
Abstract excerpt
We have shown recently (B. A. Yoshida et al., Cancer Res., 59: 5483-5487) that mitogen-activated protein kinase kinase 4 (MKK4) can suppress AT6.1 rat prostate cancer metastases in vivo. Evaluation of the expression of components of the MKK4 signaling cascade showed a loss or down-regulation of expression of MKK4 or c-Jun, a downstream mediator of MKK4, in six of eight human prostate cancer cell lines. Given...
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