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Article

Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN.

Molecular cancer - 21 Jun 2013

Sharma Pankaj, Knowell Ashley Evans, Chinaranagari Swathi, Komaragiri Shravan, Nagappan Peri, Patel Divya, Havrda Mathew C, Chaudhary Jaideep

Abstract excerpt

BACKGROUND: Inhibitor of differentiation 4 (Id4), a member of the helix-loop-helix family of transcriptional regulators has emerged as a tumor suppressor in prostate cancer. Id4 is expressed in the normal prostate where its expression is also regulated by androgens. In this study we investigated the effect of loss of Id4 (Id4-/-) on adult prostate morphology. METHODS: Histological analysis was performed on...

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Source

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Identifiers

PMID: 23786676
DOI: 10.1186/1476-4598-12-67
PMCID: PMC3694449

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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