Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The kallikrein 14 gene is down-regulated by androgen receptor signalling and harbours genetic variation that is associated with prostate tumour aggressiveness.

Biological chemistry - 1 Apr 2012

Lose Felicity, Lawrence Mitchell G, Srinivasan Srilakshmi, O'Mara Tracy, Marquart Louise, Chambers Suzanne, Gardiner Robert A, Aitken Joanne F, Spurdle Amanda B, Batra Jyotsna, Clements Judith A

Abstract excerpt

Kallikrein 14 (KLK14) has been proposed as a useful prognostic marker in prostate cancer, with expression reported to be associated with tumour characteristics such as higher stage and Gleason score. KLK14 tumour expression has also shown the potential to predict prostate cancer patients at risk of disease recurrence after radical prostatectomy. The KLKs are a remarkably hormone-responsive family of genes,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Down-Regulation

Share to Kallikreins

Share to Prostatic Neoplasms

Share to Receptors, Androgen

Share to Signal Transduction

Source

Identifiers

PMID: 22505522
DOI: 10.1515/hsz-2011-0268

Genes

KLK14

Variants

rs17728459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The kallikrein 14 gene is down-regulated by androgen receptor signalling and harbours genetic variation that is associated with prostate tumour aggressiveness.PMID 22505522Read ↗

Genetic association of the KLK4 locus with risk of prostate cancer.Semantic proximity Read ↗

Common variation in Kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness.Semantic proximity Read ↗

Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data.Semantic proximity Read ↗

Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer.Semantic proximity Read ↗

Kallikrein 4 is a Predominantly Nuclear Protein and Is Overexpressed in Prostate CancerSemantic proximity Read ↗

Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.Semantic proximity Read ↗

Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.Semantic proximity Read ↗

Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases.Semantic proximity Read ↗

The prostate cancer susceptibility variant rs2735839 near KLK3 gene is associated with aggressive prostate cancer and can stratify gleason score 7 patients.Semantic proximity Read ↗

Distinctly different gene structure of KLK4/KLK-L1/prostase/ARM1 compared with other members of the kallikrein family: intracellular localization, alternative cDNA forms, and Regulation by multiple hormones.Semantic proximity Read ↗

Genetic factors influencing prostate cancer risk in Norwegian men.Semantic proximity Read ↗

Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.