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Article

MAP2K4/MKK4 Expression in Pancreatic Cancer

15 Dec 2004

Abstract excerpt

MKK4 (MAP2K4/SEK1) is a member of the mitogen-activated protein kinase family, originally identified as a kinase involved in the stress-activated protein kinase pathway by directly phosphorylating c-Jun NH2-terminal kinase. MKK4 genetic inactivation has been observed in a subset of pancreatic carcinomas, implicating deregulation of the stress-activated protein kinase pathway in pancreatic carcinogenesis. We...

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PMID: 15623633
DOI: 10.1158/1078-0432.ccr-04-0885

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