Article
Heritability and demographic analyses in the large isolated population of Val Borbera suggest advantages in mapping complex traits genes.
PloS one - 22 Oct 2009
Traglia Michela, Sala Cinzia, Masciullo Corrado, Cverhova Valeria, Lori Francesca, Pistis Giorgio, Bione Silvia, Gasparini Paolo, Ulivi Sheila, Ciullo Marina, Nutile Teresa, Bosi Emanuele, Sirtori Marcella, Mignogna Giovanna, Rubinacci Alessandro, Buetti Iwan, Camaschella Clara, Petretto Enrico, Toniolo Daniela
Abstract excerpt
BACKGROUND: Isolated populations are a useful resource for mapping complex traits due to shared stable environment, reduced genetic complexity and extended Linkage Disequilibrium (LD) compared to the general population. Here we describe a large genetic isolate from the North West Apennines, the mountain range that runs through Italy from the North West Alps to the South. METHODOLOGY/PRINCIPAL FINDINGS: The study...
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