The developing human immune system: T‐cell receptor repertoire of children and young adults shows a wide discrepancy in the frequency of persistent oligoclonal T‐cell expansions

Abstract excerpt

While the T-cell receptor (TCR) repertoire of the newborn is highly diverse, a gradual alteration in diversity of the expressed TCR repertoire, in particular the oligoclonality of CD8+ T cells, occurs with increasing age. The timing of the initiation of this process is unknown. These changes are associated with an accumulation of T-cell expansions, thought to be in response to chronic antigen stimulation,...

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