Article
Age-related persistent clonal expansions of CD28(-) cells: phenotypic and molecular TCR analysis reveals both CD4(+) and CD4(+)CD8(+) cells with identical CDR3 sequences.
Clinical immunology and immunopathology - 1 Oct 1998
Colombatti A, Doliana R, Schiappacassi M, Argentini C, Tonutti E, Feruglio C, Sala P
Abstract excerpt
In a small group of subjects we had identified persistent expansions (range 6-72%) of CD4(+)CD8(+) double-positive (DP) peripheral blood (PB) cells which express the CD8 alpha/alpha homodimer. Here, DP cells present in a larger cohort were further investigated and found by FACS analysis to expres...
Topics
- Adult
- Aged
- Aged, 80 and over
- Aging
- Amino Acid Sequence
- Base Sequence
- CD28 Antigens
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Division
- Clone Cells
- Complementarity Determining Regions
- Female
- Genes, T-Cell Receptor beta