Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The blood of healthy individuals exhibits CD8 T cells with a highly altered TCR Vb repertoire but with an unmodified phenotype.

PloS one - 1 Jan 2011

Degauque Nicolas, Boeffard Françoise, Foucher Yohann, Ballet Caroline, Brouard Sophie, Soulillou Jean-Paul

Abstract excerpt

CD8 T cell clonal expansions (TCE) have been observed in elderly, healthy individuals as well in old mice, and have been associated with the ageing process. Both chronic latent and non-persistent viral infections have been proposed to drive the development of distinct non-functional and functional TCE respectively. Biases in TCR Vβ repertoire diversity are also recurrently observed in patients that have undergone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phenotype
Share to Receptors, Antigen, T-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Antigen, T-Cell, alpha-beta

Source

Open in PubMed Open full text

Identifiers

PMID: 21738624
DOI: 10.1371/journal.pone.0021240
PMCID: PMC3124488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The blood of healthy individuals exhibits CD8 T cells with a highly altered TCR Vb repertoire but with an unmodified phenotype.PMID 21738624Read ↗

Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly.Semantic proximity Read ↗

Longitudinal analysis reveals age-related changes in the T cell receptor repertoire of human T cell subsetsSemantic proximity Read ↗

Clonotype Selection and Composition of Human CD8 T Cells Specific for Persistent Herpes Viruses Varies with Differentiation but Is Stable Over TimeSemantic proximity Read ↗

Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire DiversitySemantic proximity Read ↗

The Polyfunctionality of Human Memory CD8+ T Cells Elicited by Acute and Chronic Virus Infections Is Not Influenced by AgeSemantic proximity Read ↗

Age-related decrease in TCR repertoire diversity measured with deep and normalized sequence profiling.Semantic proximity Read ↗

Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires.Semantic proximity Read ↗

CD8+ T Cell Senescence: Lights and Shadows in Viral Infections, Autoimmune Disorders and CancerSemantic proximity Read ↗

Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals.Semantic proximity Read ↗

Impact of age, sex and CMV-infection on peripheral T cell phenotypes: results from the Berlin BASE-II Study.Semantic proximity Read ↗

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance.Semantic proximity Read ↗

Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.