Article
Transient T cell receptor beta-chain variable region-specific expansions of CD4+ and CD8+ T cells during the early phase of pediatric human immunodeficiency virus infection: characterization of expanded cell populations by T cell receptor phenotyping.
The Journal of infectious diseases - 1 Jan 2000
Soudeyns H, Champagne P, Holloway C L, Silvestri G U, Ringuette N, Samson J, Lapointe N, Sékaly R P
Abstract excerpt
T cell receptor (TCR) repertoire perturbations are commonly detected in CD8+ T cells during adult primary human immunodeficiency virus (HIV) infection and have been associated with HIV-specific cytotoxic T cell responses. By use of flow cytometry, transient high-level TCR beta-chain variable region-specific expansions of CD4+ and CD8+ T cells were observed more frequently in HIV-infected children than in children...
Topics
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Child, Preschool
- Genes, T-Cell Receptor beta
- HIV Infections
- HIV-1
- Humans
- Infant
- Infant, Newborn
- Infectious Disease Transmission, Vertical
- Longitudinal Studies
- Lymphocyte Activation