Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional dissection of the cytoplasmic subregions of the interleukin-5 receptor alpha chain in growth and immunoglobulin G1 switch recombination of B cells.

Immunology - 1 Mar 2001

Moon B G, Yoshida T, Shiiba M, Nakao K, Katsuki M, Takaki S, Takatsu K

Abstract excerpt

The interleukin-5 receptor alpha chain (IL-5Ralpha) is known to regulate the development and function of B cells and eosinophils. Although the functions of IL-5Ralpha cytoplasmic domain subregions have been studied extensively using cultured cell lines, this approach has limitations when studying the functions of distinct primary B-cell subpopulations and their responsiveness to IL-5. In the present study, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocyte Subsets
Share to Cell Culture Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Immunoglobulin Class Switching

Share to Immunoglobulin G

Share to Immunoglobulin M

Share to Interleukin-5

Share to Receptors, Interleukin

Source

Open in PubMed Open full text

Identifiers

PMID: 11298827
DOI: 10.1046/j.1365-2567.2001.01196.x
PMCID: PMC1783180

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional dissection of the cytoplasmic subregions of the interleukin-5 receptor alpha chain in growth and immunoglobulin G1 switch recombination of B cells.PMID 11298827Read ↗

Interleukin 5 regulates the isoform expression of its own receptor α-subunitSemantic proximity Read ↗

The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis.Semantic proximity Read ↗

Stat5a/b are essential for normal lymphoid development and differentiation.Semantic proximity Read ↗

Experimental regulation of STAT gene expression reveals an involvement of STAT5 in interleukin-4-driven cell proliferation.Semantic proximity Read ↗

An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation.Semantic proximity Read ↗

Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis.Semantic proximity Read ↗

The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion.Semantic proximity Read ↗

In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif.Semantic proximity Read ↗

Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1).Semantic proximity Read ↗

Characterization of the cytoplasmic domain of interleukin-13 receptor-alpha.Semantic proximity Read ↗

A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis.Semantic proximity Read ↗

BCL6 is critical for the development of a diverse primary B cell repertoireSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.