Article
The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis.
The EMBO journal - 15 Apr 1996
Corcoran A E, Smart F M, Cowling R J, Crompton T, Owen M J, Venkitaraman A R
Abstract excerpt
The interleukin 7 receptor (IL7R), which contains a unique alpha chain and a gamma chain shared by other cytokine receptors, is indispensable for normal lymphocyte development. The basis for this role is poorly understood. Here we show that the IL7R alpha chain not only causes progenitors to prol...
Topics
- Animals
- Antigens, CD
- B-Lymphocytes
- Cell Differentiation
- Cell Division
- Gene Transfer Techniques
- Genetic Complementation Test
- Hematopoiesis
- Hematopoietic Stem Cells
- Humans
- Mice
- Mice, Knockout
- Molecular Structure
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphotransferases (Alcohol Group Acceptor)
- Protein Conformation
- Receptors, Interleukin