Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Experimental regulation of STAT gene expression reveals an involvement of STAT5 in interleukin-4-driven cell proliferation.

Biological chemistry - 1 Feb 2001

Friedrich K, Wietek S

Abstract excerpt

The precise roles of signal transducers and activators of transcription (STATs) in cytokine-triggered control of cell physiology are not sufficiently well understood. We have established cell lines in which the individual functional contributions of STAT6 and STAT5a/b to interleukin-(IL-) 3 and -4-dependent processes can be readily studied. Mutants of STAT6, STAT5a and 5b lacking the transcriptional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Green Fluorescent Proteins
Share to Interleukin-3
Share to Interleukin-4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luminescent Proteins

Share to Milk Proteins

Share to Receptors, Interleukin-4

Share to STAT5 Transcription Factor

Share to STAT6 Transcription Factor

Source

Identifiers

PMID: 11308032
DOI: 10.1515/BC.2001.041

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Experimental regulation of STAT gene expression reveals an involvement of STAT5 in interleukin-4-driven cell proliferation.PMID 11308032Read ↗

STAT5 activation is required for interleukin-9-dependent growth and transformation of lymphoid cells.Semantic proximity Read ↗

STAT proteins: From normal control of cellular events to tumorigenesisSemantic proximity Read ↗

Human B lymphoblast cell lines defective of Stat6 signaling produce high levels of proinflammatory cytokines IL-12, TNFalpha and IFNgamma.Semantic proximity Read ↗

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.Semantic proximity Read ↗

In vivo identification of novel STAT5 target genesSemantic proximity Read ↗

The STAT3 isoforms alpha and beta have unique and specific functions.Semantic proximity Read ↗

Expression of a carboxy terminally truncated Stat5 with no transactivation domain in the mammary glands of transgenic mice inhibits cell proliferation during pregnancy, delays onset of milk secretion, and induces apoptosis upon involution.Semantic proximity Read ↗

Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis.Semantic proximity Read ↗

STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells.Semantic proximity Read ↗

Ups and downs: The STAT1:STAT3 seesaw of Interferon and gp130 receptor signallingSemantic proximity Read ↗

Activation of STAT6 is not dependent on phosphotyrosine-mediated docking to the interleukin-4 receptor and can be blocked by dominant-negative mutants of both receptor subunits.Semantic proximity Read ↗

Stat proteins and oncogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.